Writing

The Regenerative Edge on Substack, plus digests on Medium. For the research directions behind them, see Research.

Ongoing Series
The Regenerative Edge

Essays on why the adult heart stops regenerating, what evolution traded away, and what it would take to get that capacity back. On Substack.

Concluded Series
CardioRegen Brief

A weekly literature digest unpacking the latest in cardiac regenerative science · biological pacemakers, heart repair, stem cell cardiology, and translational cardiology. This series has concluded.

May 25, 2026 · 1 min read
CardioRegen Brief · Week 5
Molecular gatekeepers of cardiomyocyte proliferation, in vivo reprogramming of cardiac fibroblasts, and cell cycle arrest in cardiomyocytes · three papers unpacked with clinical relevance and limitations.
Regeneration · Cardiology · Cell Biology
May 18, 2026 · 3 min read
CardioRegen Brief · Week 4: Cardiac Patches, Organoids & Reprogramming
Scalable cardiomyocyte production in bioreactors, engineered heart muscle allografts in primates and a first human case (BioVAT-HF), and fibroblast reprogramming progress in JACC.
Organoids · Tissue Engineering · Translation
May 12, 2026 · 1 min read
CardioRegen Brief · Week 3
A broad-spectrum week: stem cell technology for cardiac regeneration, post-MI repair strategies across cell therapy, in vivo reprogramming and tissue engineering, and fibroblast conversion into cardiomyocytes.
Stem Cells · Post-MI · Fibroblast Reprogramming
May 4, 2026 · 1 min read
Cardiac Regen Brief · Week 2
Primitive macrophage secretome driving cardiomyocyte proliferation, multilineage cardiac co-differentiation systems, and maturation of cardiac organoids for functional disease modeling.
Paracrine Signaling · Organoids · Maturation
Apr 27, 2026 · 2 min read
Cardiac Regen Brief · Week 1
Extracellular vesicles as cell-free cardiac therapy, metabolic control of cardiomyocyte regenerative capacity, and a documented human case of near-complete cardiac recovery in a neonate.
Extracellular Vesicles · Metabolism · Human Case
Mar 22, 2026 · 2 min read
Ticking Time Bombs: Heart Disease in Today's Youth
The silent epidemic of hypertension and high cholesterol in children and young adults · and why cardiovascular research continues to underrepresent the under-40 demographic at its own peril.
Public Health · Youth CVD · Epidemiology
Syed Publication on Substack → All posts on Medium →
© 2026 Syed Umer Hannan  ·  Cardiac Regenerative Scientist